By Hiroshi Mitsumoto MD
Amyotrophic Lateral Sclerosis offers the main complete, clinically-focused info on ALS (Lou Gehrig's affliction) in print. the 3 authors, well known for his or her paintings during this zone, offer cohesive and balanced insurance of this syndrome, together with the background, scientific good points, pathology and pathogenesis, remedy and administration of ALS. To facilitate figuring out, every one bankruptcy is more suitable via complete tables and figures, in addition to specific bankruptcy summaries.
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Extra resources for Amyotrophic Lateral Sclerosis
36. Hudson, AJ: Amyotrophic lateral sclerosis: Clinical evidence for differences in pathogenesis and etiology. In Hudson, A (ed): Amyotrophic Lateral Sclerosis. University of Toronto Press, Toronto, 1990, pp 108-143. 37. Koerner, DR: Amyotrophic lateral sclerosis on Guam: A clinical study and review of the literature. Ann Intern Med 37:1204-1220, 1952. 38. Kurland, LT and Muldeer, DW: Epidemiologic investigations of amyotrophic lateral sclerosis. Preliminary report on geographic distribution, with special reference to the Mariana Islands, including clinical and pathological observations.
Med Chir Mschr 1 (1858) summary in Arch Gen Med 13:96, 1859. 25. Gajdusek, DC: Motor-neuron disease in native of New Guinea. N Engl J Med 268:474-476, 1963. 26. Gajdusek, DC and Salazar, AM: Amyotrophic lateral sclerosis and parkinsonian syndromes in high incidence among the Auyu and Jakai people of West New Guinea. Neurology 32:107-126, 1982. 27. Goldblatt, D: Motor neuron disease: Historical introduction. In Norris, FH and Kurland, LT (eds): Motor Neuron Diseases. Grune & Stratton, New York, 1969, pp 3-11.
Here, we will use the term ALS to encompass all these types of motor neuron degeneration because most cases eventually progress to become classic ALS. 84,110,131 True progressive bulbar palsy is rare and progressive spinal muscular atrophy is uncommon (see Chapter 1). 106 The terminology and definition of ALS are discussed in detail in Chapter 1. 12,20,92,105,107,155 Epidemiology DEFINITIONS AND CASE IDENTIFICATION IN ALS EPIDEMIOLOGY Definitions The frequency of ALS in the population can be represented by its incidence (the number of newly identified patients per year) or by its prevalence (the number of surviving patients at any given time).